Application of a Library of Artificial Receptors Formed by Self-Organization of N-Lipidated Peptides Immobilized on Cellulose for Preliminary Studies of Binding of N-Phenylpiperazines

摘要

A library of artificial receptors formed by self-organization of N-lipidated peptides attached to cellulose via aminophenylamino-l,3,5-triazine was synthesized and used for docking small, colorless guests. Interactions of colorless guest with receptors were visualized by using competitive adsorption-desorption of appropriate reporter dye. Analysis of binding pattern of N-phenylpiperazine derivatives with gradually increased lipophilicity was found diagnostic for structural changes of guest molecules. Several library members demonstrated attributes characteristic for detection of alteration of lipophilicity of the guest structure.