Azide synthesis in microstructured flow systems

摘要

A process for synthesising organic azides starting from the corresponding amine is elaborated. It enables the safe handling of a diazo intermediate (stage 1) and its subsequent treatment with sodium azide (stage 2). Accumulation of critical product was prevented by injection of an organic solvent prior to stage 2 followed by instant extraction. In order to minimise all risks arising from potentially formed hydrazoic acid the aqueous product phase was continuously separated and inactivated. This enabled the daily manufacturing of 4.5-6 litre of azide solution in 0.5 M standard concentration.