Microarrays promise to advance biology through the parallel screening for many different binding partners. In the field of DNA microarrays lithographic techniques enables the combinatorial synthesis in densities of several ten thousand oligonucleotides per cm~2. The availability of such high dense screening tools revolutionized the field of genomics. A similar development is expected for the field of proteomics, but was hindered in past times by low densities and the lack of an adequate diversity in peptide array production. This article describes recent developments in this field with an emphasis on methods that have the potency to overcome the obstacles in peptide synthesis and lead to affordable very high density peptide arrays.
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