A New Alternative for Selective Fluorination: TFEDMA (1,1,2,2 - Tetrafluoroethyl-N,N-Dimethylamine)

摘要

The introduction of fluorine into organic compounds by fluorodehydroxylation of readily available alcohols is a convenient and increasingly popular synthetic technique. One of the most versatile reagents for this transformation is 1,1,2,2-tetrafluoroethyl-N,N-dimethylamine, TFEDMA. TFEDMA derives from tetrafluoroethylene, one of the largest volume commercial fluoroolefines. It is stable at ambient temperature when stored in a Teflon~(TM) or metal container. Glass apparatus can be used for distillation at reduced pressure, but is attacked at elevated temperatures.