Biotransformation of triptonide by cell suspension cultures of platycodon grandiflorum

摘要

The biotransformation of triptonide by cell suspension cultures of Platycodon grandiflorum was investigated.After six days of incubation,five products were obtained. On the basis of ch4emcial and spectralevidence,their structures were elucidated as epitritolide-14-O-beta-D-glucoside,5alpha-hydroxytriptonide,triptolide,triptodiolide,and 2beta 2beta-hydroxytriptonide,among which epitriptolide-14-O-beta-D-glucoside and 5alpha-hydroxytriptonide are new compounds.