NOVEL BIOTRANSFORMATIONS ON PERACYLATED POLYPHENOLICS BY LIPASES IMMOBILIZED IN MICROEMULSION-BASED GELS AND ON CARBOHYDRATES BY CANDIDA ANTARTICA LIPASE

摘要

The lipases from porcine pancreas (PPL) and Candida cylindracea (CCL), solubilized in AOT [sodium bis-(2-ethylhexyl) sulphosuccinate] water-in-oil (w/o) microemulsions and supported on gelatin have been used for selective deacylations of perpropanoates and peracetates of different classes of polyphenolics. In addition, lipase from Candida antartica (Novozym 435) has been used for regioselective propanoylation of 2-deoxy-D-ribose and D-ribose, the products on subsequent acetylation with acetic anhydride/pyridine afforded the corresponding tri- and tetraacyl derivatives, universal synthones for the synthesis of 2'-deoxyribonucleosides and ribonucleosides, respectively. An attempt has; also been made to synthesise acylated erythrooxetanose using the same methodology. [References: 24]