Pregabalin in the treatment of posttraumatic stress disorder: a case report.

摘要

Posttraumatic stress disorder (PTSD) includes the three symptom clusters reexperiencing, avoidance and numbing, and hyperarousal. Cognitive-behavioral therapies are recommended as first-line treatment for PTSD (Bisson and Andrew, 2007). In a Cochrane-review, Stein et al. (2006) have demonstrated the efficacy of antidepressants (tricyclic antidepressants, MAO-inhibitors and especially SSRIs, e.g. sertraline, paroxetine) as first-line medications for PTSD (degree of evidence: la). In Europe, pregabalin has been approved for the treatment of generalised anxiety disorders (GAD). Up to now there have been no controlled trials on the use of pregabalin in PTSD.