Clozapine-induced sialorrhea (CIS) occurs in about 30% of patients treated with this medication (Praharaj et al., 2006). It is a socially stigmatizing adverse effect for the patients interfering with their quality of life and often leading to discontinuation of treatment. While non-pharmacological strategies to address CIS can be used alone in milder cases, in most cases it is difficult to treat and majority of the available pharmacological treatment options have either limited efficacy or unwanted side-effects (Gaftanyuk and Trestman, 2004). Glycopyrrolate is an anti-muscarinic drug, which is known for its potent drying property and is popular with the anesthesiologists as a preanesthetic agent (Blasco and Stansbury, 1996). It has been used to effectively treat chronic drooling in children and young adults with developmental delays (Blasco and Stansbury, 1996; Mier et al., 2000; Stern, 1997). As per a review on management strategies for clozapine-induced sialorrhea, there are no reports describing the use of glycopyrrolate for this adverse effect (Praharaj et al., 2006). A case of effective use of glycopyrrolate for clozapine-induced sialorrhea is described.
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机译：使用这种药物治疗的患者中约有30％发生氯氮平诱导的腹泻（CIS）（Praharaj等，2006）。对于患者来说，这是一种社会污名化的不良反应，干扰了他们的生活质量，并经常导致治疗中断。虽然在较温和的情况下可以单独使用非药物策略来治疗CIS，但在大多数情况下很难治疗，并且大多数可用的药物治疗方案疗效有限或不良副作用（Gaftanyuk和Trestman，2004）。格隆溴铵是一种抗毒蕈碱药物，以其强大的干燥性能而闻名，在麻醉学家中作为麻醉剂被广泛使用（Blasco and Stansbury，1996）。它已被用来有效地治疗儿童和年轻成人的慢性流口水，并伴有发育迟缓（Blasco和Stansbury，1996; Mier等，2000; Stern，1997）。根据氯氮平诱导的腹泻的治疗策略的综述，尚无报道描述使用格隆溴铵治疗这种不良反应（Praharaj等，2006）。有效地使用格隆溴铵治疗氯氮平诱发的腹泻的案例。
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