A new, microalgal DHA- and EPA-containing oil lowers triacylglycerols | in adults with mild-to-moderate hypertriglyceridemia

摘要

In this double-blind, parallel trial, 93 healthy adults with hypertriglyceridemia (triacylglycerols [TAG] 150-499 mg/dL) were randomized to receive either a nutritional oil derived from marine algae (DHA-0; 2.4g/day docosahexaenoic acid [DHA] and eicosapentaenoic acid [EPA] in a 2.7:1 ratio}, fish oil (FO; 2.0 g/day DHA and EPA in a 0.7:1 ratio), or a corn oil/soy oil control as 4-1 g softgel capsules/day with meals for 14 weeks; and were instructed to maintain their habitual diet. Percent changes from baseline for DHA-O, FO, and control, respectively, were TAG (-18.9, -22.9, 3.5; p< 0.001 DHA-0 and FO vs. control), low-density lipoprotein cholesterol (4.6, 6.8, -0.6; p<0.05 DHA-0 and FO vs. control), and high-density lipoprotein cholesterol (4.3, 6.9, 0.6; p < 0.05 FO vs. control). This study demonstrated that ingestion of microalgal DHA-0 providing 2.4 g/day DHA+EPA lowered TAG levels to a degree that was not different from that of a standard fish oil product, and that was significantly more than for a corn oil/ soy oil control.