Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential for murine CD4+ T cell metabolic activation

摘要

Glycerol 3-phosphateacyltransferase-l [GPAT-1] is an integral mitochondrial membrane protein responsible for conjugating fatty acyl-CoA with glycerol-3 phosphate in the first rate limiting step of de novo glycerophospholipid synthesis [1]. GPAT-1 catalyzes the conversion of glycerol-3 phosphate and acyl-CoA to lysophosphatidic acid (LPA), which is then further acylated to phosphatidic acid, which subsequently serves as a precursor for all glycerophospholipid (GPL) and triglyceride synthesis. The acyl-CoA pool used by GPAT-1 can also be processed by carnitine palmitoyltransferase-1 (CPT1) for transport into the mitochondria for p-oxidation since both proteins are located in the mitochondria. GPAT-1 and CPT-1 compete for acyl-CoAs thereby playing a role in dictating whether a fatty acid is used for energy production (oxidation) or synthesis of more complex lipids (GPL and triglyceride).