The dimeric structure of Sulfolobus solfataricus thioredoxin A2 and the basis of its thermostability

摘要

Living organisms have developed efficient biological mechanisms for scavenging reactive oxygen species produced by metabolism. The thioredoxin system, composed by thioredoxin (Trx), thioredoxin reductase (TrxR), and NADPH plays a crucial role in regulating the redox state of the cell and in protecting them against oxi-dative stress. Although this system is ubiquitous among organisms of all three domains of life, most of the functional and structural investigations have been hitherto focused on eukaryal and eubacteryal Trx systems. Limited information is indeed available for enzymes involved in the Trx system of archaea.