Lactoferrin inhibits lipid peroxidation in chronic hepatitis C patients

摘要

Oxidative stress plays an important role in the patholo-genesis of chronic hepatitis C (CHC). Trials with antioxidants have been carried out to influence the progress of the disease. Bovine lactoferrin (bLF), a milk protein of the iron-transporter family, is commercially available as a health food in Japan. Previous studies have shown that LF inhibits lipid peroxidation in vitro. The present study evaluated the effects of bLF on plasma 8-isoprostane, serum aminotransferase levels, viral load, and iron metabolism markers in patients with CHC.