Carbohydrate-based mimetics in drug design:sugar amino acids and carbohydrate scaffolds

摘要

Among the major classes of biomolecules,carbohydrates allow almost unlimited structural variations.The molecular diversity of carbohydrates offers a valuable tol for drug discovery in the areas of biologically important oligosaccharides,glycoconjugates,and molecular scaffolds by investigating their structural andfunctional impact.Themodifications such as those of the naturally occurring O-/N-glycosidic bonds remain of interest to increase the enzymatic stability,as well as to facilitate the assembly of large,divers eoigomer carbohdrate or peptidomimetic libraries by solid-phase techniques.