Mobilisation of triacylglycerol stores


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Triacylglycerol (TAG) is an energy dense substance which is stored by several body tissues, principally adipose tissue and the liver. Utilisation of stored TAG as an energy source requires its mobilisation from these depots and transfer into the blood plasma. The means by which TAG is mobilised differs in adipose tissue and liver although the regulation of lipid metabolism in each of these organs is interdependent and synchronised in an integrated manner. This review deals principally with the mechanism of hepatic TAG mobilisation since this is a rapidly expanding area of research and may have important implications for the regulation of plasma very-low-density lipoprotein metabolism. TAG mobilisation plays an important role in fuel selection in non-hepatic tissues such as cardiac muscle and pancreatic islets and these aspects are also reviewed briefly. Finally, studies of certain rare inherited disorders of neutral lipid storage and mobilisation may provide useful information about the normal enzymology of TAG mobilisation in healthy tissues.
机译:三酰基甘油(TAG)是一种能量密集型物质,可以存储在多个人体组织中,主要是脂肪组织和肝脏。利用存储的TAG作为能源需要从这些仓库中动员并转移到血浆中。 TAG的动员方式在脂肪组织和肝脏中有所不同,尽管这些器官中每个器官的脂质代谢调控是相互依存的,并且以整合的方式同步进行。这项审查主要涉及肝TAG动员的机制,因为这是一个快速扩展的研究领域,可能对血浆超低密度脂蛋白代谢的调节具有重要意义。 TAG动员在非肝组织(如心肌和胰岛)的燃料选择中起着重要作用,这些方面也作了简要回顾。最后,对某些罕见的中性脂质存储和动员的遗传性疾病的研究可能会提供有关健康组织中TAG动员的正常酶学的有用信息。



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