Elevation in the serum and urine concentration of injury-related molecules after the formation of deep tissue injury in a rat spinal cord injury pressure ulcer model.

摘要

The diagnosis of deep tissue injury (DTI) is currently still vague [1], with only subjective methods available for quantification. Tools are missing for clinicians to objectively sense DTI under the intact skin, which hampers the development of evidence-based practice for early diagnosis and treatment. Several molecules [2-9] have been reported as indicating muscle injury because they are released during skeletal muscle damage and subsequent inflammation [10]. Myoglobin (MB) [2,6], heart-type fatty acid binding protein (H-FABP) [2,8,9], myosin [4], and troponin-I (Tnl) [6] have shown significant increases after severe skeletal muscle injury, whereas hydroxyproline (HP) is released during collagen breakdown in tissue damage [9]. Common biomarkers for tissue injury-related inflammation are creatine kinase (CK) [7,8,11], and alpha1-acid glycoprotein (alpha1-AGP) [12]. The objective of this study was to examine the concentration of these molecules in blood and/or urine on a spinal cord injury (SCI)-DTI rat model [13] during DTI formation to initially assess their potential as the biomarkers indicating the onset of a DTI.