The use of surface plasmon resonance and atomic forcf. microscopy for the study of protein adsorption to model and protein-resistant Polymer Surfaces

摘要

The surface chemistry ot' polymeric hiorrmterialshas u muwr impact on'their laie in-vivo. Interactions between synthetic materials and the biological milieu may result in host tissue biocumpatihility problems. In an attempt to understand this process, the adsorption ot' a range ot proteins to a variety of polymeric substrates has been extensively reported in the literature. A range of proteins and analytical instrumentation have been employed to characterize the protein deposition. In this paper, we highlight the potential of two surface analytical techniques, surface piasmon resonance (SPRu and atomic force microscopy (AFM) for the analysis of protein adsorption to polymer surfaces us tollows.