Controlled radical polymerization of N-isopropylacrylmide and of activated esters for the synthesis of polymer-protein and polymer-drug conjugates

摘要

Recently, the synthesis of polymers via reversible addition-fragmentation chain transfer (RAFT) polymerization has gained importance due to its great versatility, its compatibility with a wide range of monomers, the control of the molecular weights, and the low polydispersities of the resultant polymers. Besides, it offers all advantages of conventional free radical polymerization. The polymerization is carried out in the presence of thiocarbonylthio compounds of general structure Z-C(=S)S-R and results in the formation of end-functionalized polymers.