Preparation and properties of core-shell alginate-carboxymethylchitosan hydrogels

摘要

BACKGROUND: Hydrogels of alginate (ALG) with partially carboxymethylated chitosan (CMCHI) have been produced for drug delivery, based on the interactions between the negative groups and an ionic crosslinker. In the present work, CMCHI was used to evaluate the influence of amino groups that are positively charged at pH = 4 and 6 on the ALG-CMCHI core-shell hydrogel preparation. An ANOVA statistics tool was used to evaluate the effect of composition, pH and chitosan chemical nature on the morphology and swelling properties of the hydrogels in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). RESULTS: The ALG-CMCHI core-shell hydrogels presented smaller (ca 2.3 μm) and more homogeneous microparticles than those with unmodified chitosan (ca 5.5 μm). The ALG-CMCHI hydrogels showed higher thermal stability and lower degree of swelling in SGF (314%) compared to those with chitosan (708%), since in the former hydrogels the protective layers that surround the particles are negatively charged. CONCLUSION: CMCHI can replace chitosan in the production of core-shell hydrogels with improved properties since the negative charge surrounding the ALG-CMCHI particles favours a lower degree of swelling. The results point out a possible prevention of burst release in SGF, sustaining the swelling ability of the ALG-CMCHI core-shell hydrogels in SIF, promising appropriate drug release.