Synthesis and evaluation of biodegradable segmented multiblock poly(ether ester) copolymers for biomaterial applications

摘要

Based on 1,4-succinic acid, 1,4-butanediol, poly(ethylene glycol)s and dimethyl terephthalate, biodegradable segmented multiblock copolymers of poly[(butylene terephthalate)-co-poly(butylene succinate)-block-poly(ethylene glycol)] (PTSG) were synthesized with different poly(butylene succinate) (PBS) molar fractions and varying the poly(ethylene glycol) (PEG) segment length, and were evaluated as biomedical materials. The copolymer extracts showed no in vitro cytotoxicity. However, sterilization of the copolymers by gamma irradiation had some limited effect on the cytotoxicity and mechanical properties. A copolymer consisting of PEG-1000 and 20 mol% PBS, assigned as 1000PBS20 after SO2 gas plasma treatment, sustained the adhesion and growth of dog vascular smooth muscle cells. The in vivo biocompatibility of this sample was also measured subcutaneously in rats for 4 weeks. The assessments indicated that these poly(ether ester) copolymers are good candidates for anti-adhesion barrier and drug controlled-release applications. (C) 2004 Society of Chemical Industry.