Synthesis of hydrolytically stable low elastic modulus polyurethane-urea for biomedical applications

摘要

Polyurethane-urea wihtout ether linkages was synthesised using dicyclohexyl-methane diisocyanate(SMDI), hydroxy-terminated polybutadiene(HTPBD) and m-phenylenediamine(PDA). The hydrolytic stability of this polymer was investigated under in vitro conditions using Ringer's solution and phosphate-buffered saline, and the stability of candidate polyurethane-urea polymers was compared with that of polyurethane prepared with SMDI, HTPBD and 1,4-butanediol [BD]. The change of tensile properties, hardness and surface properties in the aged polymer is significant for polyurethane when compared with those of polyurethane-urea polymer. The in vitro study revealed possible applications of polyurethane-urea for long-term biomedical applications.