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Alpha-melanocyte stimulating hormone has beneficial effects on cerulein-induced acute pancreatitis.

机译:刺激α-黑素细胞的激素对青霉素诱导的急性胰腺炎具有有益的作用。

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摘要

We investigated the effect of alpha-melanocyte stimulating hormone (alpha-MSH) on cerulein induced acute pancreatitis in rats. alpha-MSH treatment (50 microg per rat, intraperitoneally) prior to cerulein reduced the plasma amylase level, pancreatic weight, pancreatic myeloperoxidase activity and the severity of the lesions microscopically. These data suggest that alpha-MSH has a protective effect on cerulein-induced acute pancreatitis and this effect could be attributed, at least in part, to decreased tissue leukocyte infiltration and thus, to decreased pro-inflammatory cytokine production and/or oxygen- and nitrogen-derived reactive metabolite release.
机译:我们调查了α-黑素细胞刺激激素(α-MSH)对小分子诱导的大鼠急性胰腺炎的影响。在小分子纤维素之前进行alpha-MSH处理(每只大鼠腹膜内50微克)可在显微镜下降低血浆淀粉酶水平,胰腺重量,胰腺髓过氧化物酶活性和病变的严重程度。这些数据表明,α-MSH对青霉素诱导的急性胰腺炎具有保护作用,这种作用至少可以部分归因于组织白细胞浸润的减少,因此,促炎性细胞因子的产生和/或氧和/或氧的减少。氮衍生的反应性代谢物释放。

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