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The kallikrein-kininogen-kinin system: lessons from the quantification of endogenous kinins.

机译:激肽释放酶激肽原激肽系统:内源激肽定量的经验教训。

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摘要

The purpose of the present review is to describe the place of endogenous kinins, mainly bradykinin (BK) and des-Arg(9)-BK in the kallikrein-kininogen-kinin system, to review and compare the different analytical methods reported for the assessment of endogenous kinins, to explain the difficulties and the pitfalls for their quantifications in biologic samples and finally to see how the results obtained by these methods could complement and extend the pharmacological evidence of their pathophysiological role.
机译:本文的目的是描述激肽释放酶激肽原激肽系统中内源激肽的主要位置,主要是缓激肽(BK)和des-Arg(9)-BK,以审查和比较评估中报告的不同分析方法内源激肽的作用,解释其在生物样品中定量分析的困难和陷阱,最后了解通过这些方法获得的结果如何补充和扩展其病理生理作用的药理学证据。

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