Interplay Between Malaria, Crystalline Hemozoin Formation, and Antimalarial Drug Action and Design

摘要

The review represents the fruits, the offshoot, one may say, that may be reaped from the experience and knowledge gleaned from a collaborative effort, extending for more than a quarter of a century, on the design and use of auxiliaries for the control of crystal nucleation, morphology, and polymorphism, the structure determination of mono- and multilayer films of amphiphilic molecules by grazing incidence synchrotron X-ray diffraction at the air-liquid interface, and computational studies of molecular interactions at interfaces and in the crystal bulk. These studies have been conducted in close collaboration with Meir Lahav and with other colleagues.