cis-1-Amino-2-indanol in Drug Design and Applications to Asymmetric Processes

摘要

Natural products generally exist as a single enantiomer as a consequence of the inherent chirality of the enzymes that produce them.Furthermore,enzymes,receptors,and other binding sites in biological systems recognize compounds with a specific chirality.Enantiomers of a chiral molecule can display different biological activities,and in extreme cases,one enantiomer is an active drug and the other exhibits fatal toxicity.As a consequence of the FDA's 1992 directive on stereoisomers,studies on therapeutic profiles of single enantiomers of several drugs were launched.