Advances in the Total Synthesis of Biologically Important Marine Macrolides

摘要

Marine organisms,particularly sponge invertebrates and associated bacteria,are enormously rich sources of structurally diverse secondary metabolites with unique molecular architectures.These marine natural products often possess unusual and sometimes unexpected biological activities,making them valuable molecular probes for the investigation of biochemical pathways.Among these fascinating and eye-catching structures,a prominent class is the marine macrolides-highly oxygenated and stere-ochemically elaborate polyketides having a macro-cyclic lactone as a conformational constraint.