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Problems and Pitfalls in the Evaluation and Design of New Biocides for Plastics Applications

机译:塑料新型杀菌剂的评价与设计中的问题与误区

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摘要

Many factors need to be considered in the design of new biocides for use in plastics applications. In Europe, biocides are now becoming more tightly regulated under the Biocidal Products Directive (BPD), and a significant data package needs to be provided not only for the registration of new actives, but also for existing biocides and biocidal formulations. A novel biocide must be compatible with the polymer matrix and must not adversely affect its physical properties. Once the issue of compatibility has been overcome, the antimicrobial efficacy of the biocide in the substrate should be established. Before selecting a test method to demonstrate such efficacy, it is necessary to consider whether the substrate should be pre-conditioned to simulate end use conditions, e.g. by leaching or artificial weathering. The fine use of the product can also dictate the test protocol, e.g. a building membrane for ground contact should evaluated using a soil burial test. Historically, biocides have been added to plastics to prevent their spoilage by fngal attack. Advantages and disadvantages of traditional test methods will be discussed, and an alteranative method for the evaluation of biocidal performance that is thought to be more representative of end use conditions will be presented.
机译:在设计用于塑料应用的新型杀菌剂时,需要考虑许多因素。在欧洲,杀生物剂现在正受到《杀生物剂产品指令》(BPD)的更严格管制,不仅需要提供大量数据包,不仅用于注册新的活性成分,还需要提供现有的杀生物剂和杀生物剂配方。新型杀菌剂必须与聚合物基质相容,并且不得对其物理性质产生不利影响。一旦解决了相容性问题,就应确定底物中杀菌剂的抗菌功效。在选择一种证明这种功效的测试方法之前,有必要考虑是否应对底物进行预处理以模拟最终使用条件,例如:通过浸出或人工风化。产品的良好使用也可以决定测试方案,例如用于地面接触的建筑膜应使用土壤掩埋测试进行评估。从历史上看,杀生物剂已被添加到塑料中,以防止其因真菌侵袭而变质。将讨论传统测试方法的优缺点,并且将提出一种评估杀生物性能的替代方法,认为该方法更能代表最终使用条件。

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