An Aromatic Macromolecule as a Nano Drug Carrier: Polyether Dendrimer / Poly(2-hydroxyethyl methacrylate)

摘要

Highly branched, functionalized polymers have the potential to act as efficient drug carrier systems. The aromatic polyether dendrimers are spherical, highly ordered, multibranched, nanometre-sized macromolecules having positively charged ether groups on the surface under physiological conditions. In this study, we have synthesized a kind of dendrimer/poly(2-hydroxy ethyl methacrylate) nanocomposite/5-aminosalicylic acid (5-ASA) for oral drug delivery. The aromatic polyether dendrimer (generation 2, hyperbranched polyether with -CH2OH functionality, 3,5-Dihydroxybenzoic acid core) was prepared from generation 2, hyperbranched polyether dendrimer with -COOCH3 form in excellent yield. FT-IR, ~1H-NMR and DSC studies suggest that the monomer predominantly forms a complex with polyether dendrimers because of the interaction between the -CH2OH end groups of dendrimer and the -OH group of 2-hydroxyethyl methacrylate monomer.