Bionanocomposites Based on Alginate and Chitosan/Layered Double Hydroxide With Ciprofloxacin Drug: Investigation of Structure and Controlled Release Properties

摘要

In this research work, the antibiotic drug Ciprofloxacin (CFX) was intercalated into interlayer space of Zn/Al layered double hydroxides (LDH) by coprecipitation method and CFX-LDH nanohybride was obtained. Then, the Alginate/LDH and Chitosan/LDH bionanocomposites were prepared by coating of CFX-LDH nanohybride with Alginate and Chitosan. The LDH-CFX nanohybride and the bionanocomposites were characterized using the powder X-ray diffraction, the scanning electron microscope, the thermogravimetric analyses, and the Fourier transform infrared spectroscopy. In vitro release behavior of the CFX from LDH and bionanocomposites is observed in buffer solution under pH conditions (pH = 1.2, 6.8, 7.4) which have been chosen from a model of the passage materials through the gastrointestinal tract. (C) 2014 Society of Plastics Engineers.