NEUTRAL GADOLINIUM(III) COMPLEXES OF BULKY OCTADENTATE DTPA DERIVATIVES AS POTENTIAL CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING

摘要

A series of bulky and neutral gadolinium complexes of [bis(R-amide)dtpaH(3)] (where R = Pr-i, Bu(i), Bz and phenylethyl, L(1)-L(4)) with potential application as contrast agents for magnetic resonance imaging has been prepared and characterized; the relaxivity of these complexes is comparable to the contrast agent [Gd(dtpa)(H2O)](2-) which is currently used in clinics; the X-ray structure analysis of the gadolinium(III) complex of L(3) reveals a neutral nine-coordinate complex featuring a water molecule in the tricapped trigonal prismatic metal coordination sphere. [References: 15]