Design, structural and spectroscopic elucidation, and the in vitro biological activities of new triorganotin dithiocarbamates - Part II

摘要

The two novel dithiocarbamate salts, [Na{S_2CNR(R~1)}] (i), [Na{S_2CNR(R~2)}] (ii), R = methyl, R~1 = CH_2 CH(OMe)_2, R~2 = 2-methyl-1,3-dioxolane, previously synthesized by us, have been used in chemical reactions with triorganotin halides. Hence, five new complexes: [SnPh_3{S_2CNR(R~1)}] (1), [SnCy_3{S_2CNR(R~1)}] (2), [SnMe_3{S_2CNR(R~2)}] (3), [SnPh_3{S_2CNR(R~2)}] (4) and [SnCy_3{S_2CNR(R~2)}] (5), [R = methyl, R~1 = CH_2 CH(OMe)_2, and R~2 = 2-methyl-1,3-dioxolane], have been isolated. All compounds were authenticated in terms of infrared, ~1H and ~(13)C NMR, and the complexes were also characterized using ~(119)Sn NMR, ~(119)Sn M?ssbauer and X-ray crystallography, in the case of complexes (1), (4) and (5). The biological activity of all derivatives has been screened in terms of IC90 (lmol L~(-1)) and IC50 (lmol L~(-1)) against Aspergillus flavus, Aspergillus niger, Aspergillus parasiticus and Penicillium citrinum, and the results correlated well with a performed study of structure-activity relationship (SAR). Complexes (1) and (4) displayed nanomolar inhibition concentration in terms of IC_(50).