Interaction of ruthenium(II) and ruthenium(III) ions with 5-methyl-1,2,4-triazolo[1,5-a]pyrimidin-7(4H)-one

摘要

Ru(II) and Ru(III) complexes with 5-methyl-1,2,4-triazolo[1,5-a]pyrimidin- 7(4H)-one (HmtpO) of the formula cis-[RuCl_2(dmso)_3(HmtpO)] (1) and trans-[RuCl_4(dmso)(H_2mtpO)]·4H _2O (2) have been synthesized and characterized using different spectroscopic techniques (IR, ~1H-~(15)N HMBC, ~1H-~(13)C HSQC, ~1H-~(13)C HMBC and EPR). Spectroscopic studies reveal a monodentate coordination of the heterocycle ligand (HmtpO) via N3 to the ruthenium(II) and ruthenium(III) ions. In addition, the X-ray crystal structure was determined for complex (2). The compound crystallized in the triclinic group P1?. The asymmetric unit of the structure consists of two complex molecules (2a and 2b) and 8 water molecules. The equatorial positions are occupied by four chloride ions, while the N3 bonded, protonated H_2mtpO~+ and S-bonded dmso ligands are located in axial positions. Complex (1) has been screened for in vitro cytotoxicity against two human cells: non-small cell lung carcinoma (A549) and breast cancer (T47D). The ruthenium(II) complex was found to be less active than cisplatinum.