Studies on Schiff Base Complexes of Salicylaldehyde with Sulphamethoxazole and Their Antimicrobial Activities

摘要

New neutral Schiff base complexes of Cu(II),Co(II),Ni(II)and Zn(II)derived from salicylaldehyde and sulphamethoxazole have been synthesized.The structural features of the complexes have been confirmed by microanalytical data,IR,UV-Vis and EPR techniques.The electronic absorption spectra and magnetic susceptibility measurement values of the complexes indicate square-planar geometry for copper and nickel and tetra-hedral for cobalt and zinc complexes.The neutral nature of the complexes follows from their low molar conductance values.The EPR spectrum of copper complex in DMSO at 300 K and 77 K was recorded and its salient features are reported.The antimicrobial activity of the complexes has been extensively studied on microorganisms such as Staphylococcus aureus,Bacillus subtilis,Escherichia coli and Pseudomonas aeruginosa by well-diffusion technique using DMSO as a solvent.The values of zone of inhibition were found out at 37 deg C for a period of 24 h.It has been found that all the studied complexes have higher activity than the free ligand and the standard.