Synthesis of Conjugates of Amino-Combretastatin with Tuftsin Derivatives as Potential Anticancer Agents

摘要

Novel 3'-N-(tuftsin or retro-tuftsin)-amino-combretastatin conjugates have been synthesized as potential anticancer compounds. We hope that the conjugation of im-munomodulators like tuftsin derivatives with amino-combretastatin A-4 would improve the therapeutical properties of combretastatin A-4.