Free Radical Addition and Cyclization Reactions of [2-(4-(S)-Isopropyl-2-oxazoline)-5-phenyl]dialkyltin Hydrides

摘要

Radical addition reactions of [2-(4-(S)-isopropyl-2-oxazoline)~5-phenyl]dibutyl and dimethyl hydrides to activated double/triple bonds took place in good yields.Triethylborane in presence of oxygen can serve as a radical initiator.Addition of stannyl radicals toN,N-(2-methoxycarbonyl-allyl)benzyl glycinate results in formation of the corresponding piperidine derivatives.The intramolecular tandem radical addi-tion/cyclization process can be performed in high yields and good diastereoselectivity.