Synthesis,Characterization and Antimicrobial Activities of Some Metal Complexes with N'-(2-Chloro-benzoyl)thiourea Ligands:The Crystal Structure of fac-[CoL_3] and cis-[PdL_2]

摘要

We report the synthesis,structural characterization and antimicrobial activities of N,N-dimethyl-N'-(2-chloro-benzoyl)thiourea (L~1H) and N-pyrrolidine-N'-(2-chloro-benzoyl)thiourea (L~2H) and their Ni(II),Cu(II),Zn(II),Pt(II),Pd(II) and Co(III) complexes.The structure of the prepared compounds was investigated by using elemental analyses,IR,H-NMR,UV-Vis,mass spectra and magnetic susceptibility.The prepared compounds were screened for their in vitro antibacterial and antifungal activities.All compounds showed antimicrobial activity,however,the antibacterial efficacy is better than antifungal activity.Molecular structures of Co(L~1)3 and Pd(L~1)2 were determined by single crystal X-ray diffraction methods.The ligands coordinate to Ni(II),Cu(II),Zn(II),Pt(II) and Pd(II) in a bidentate manner yielding essentially neutral complexes of the type ML2.The coordination polyhedra around the Co(III) ion are distorted octahedra.