Synthesis and Characterization of Novel Phosphorictriamide Derivatives with Morpholine Substituents: Crystal Structures of (CF3)C(O)NHP(O)(NC4H8O)2 and (p-Br-C6H4)C(O)NHP(O)(NC4H8O)2

摘要

Using phosphorus pentachloride as a substrate,carbacylamidophosphates of the general formula (R)C(O)NHP(O)(NC4H8O)2,where R = CH2Cl I;CHCl2 II;CCl3 III;CF3 IV;p-Me-C6H4 V;p-Br-C6H4 VI;p-Cl-C6H4 VII,were prepared and characterized by 1H,31P and 13C NMR,IR spectroscopy and elemental analysis.Different carboxylic amides attached to phosphorus nuclei affect on IR and NMR spectra.Three-bond coupling constants between phosphorus and carbon nucleus,3J(P,C_(aliphatic)) in the synthesized compounds,were greater than two-bond coupling constants,2J(P,C_(aliphatic)).The structures of IV and VI were determined by single-crystal X-ray diffraction techniques.The compounds IV and VI formed centrosymmetric dimers via intermolecularN-H...O=P hydrogen bonds.