Synthesis,Characterization,Spectroscopic and Antimicrobial Activity Studies of Pyrimidine Dithiocarbamate Macrocyclic Complexes

摘要

The ligands disodium salts of thiobarbituric acid (Na_2L~1) and 5,5-diethylbarbituric acid (Na_2L~2) and their transition metal complexes of the type [M_2(L~1 )_2] and [M_2(L~2)_2],where M=Mn(II),Co(II),Ni(II),Cu(II),Zn(II),have been synthesized.The transition metal(II) complexes have been characterized by a range of techniques including IR,~1H NMR,UV-visible spectroscopy,magnetic moment measurements,elemental analyses and molar conductance measurements.The spectroscopic studies indicate,that the reaction of L~1 and L~2 with a divalent metal ions form binuclear dithiocarbamate macrocyclic complexes.The molar conductivity measurements suggest,that all of the complexes are non-electrolytes.The magnetic moment values and electronic spectra reveal that the Ni(II) and Cu(II) complexes are square-planar,while Mn(II),Co(II) and Zn(II) complexes are tetrahedral.All of the compounds have been screened for antimicrobial activity against Staphylococcus aureus (gram-positive bacteria) and Escherichia coli (gram-negative bacteria).The results show that all the compounds inhibit the growth of bacteria.All the complexes showed better activity as compared with the ligands.