Inhibitory Activity of Phenolic Glycosides from the Fruits of Idesia polycarpa on Lipopolysaccharide-Induced Nitric Oxide Production in BV2 Microglia.

摘要

Two new phenolic glycosides characterized as idesin salicylate ( 1) and 2-hydroxyphenol-1- O- beta- D-glucopyranosyl-(6-->1)- alpha- L-rhamnopyranoside ( 2) were isolated with four known compounds, idescarpin ( 3), idesin ( 4), 1-hydroxy-6-oxocyclohex-2-enecarboxylic acid methyl ester ( 5) and salirepin ( 6), from the fruits of IDESIA POLYCARPA. All six compounds significantly inhibited lipopolysaccharide-induced nitric oxide production in BV2 microglia at concentrations from 1 muM to 100 muM.