Structure-Activity Relationships of Flavonoids, Isolated from Scutellaria baicalensis, Binding to Benzodiazepine Site of GABAA Receptor Complex.

摘要

Twenty-six flavonoids were isolated from Scutellaria baicalensis. Their affinities for the benzodiazepine (BDZ) binding site of GABA A receptor have been studied using [ 3H]flunitrazepam binding to rat cortical membranes in vitro. The structure-activity relationships suggested that 2'-OH flavones exhibited the most potent binding affinity, which could lead to the design and discovery of new BDZ receptor ligands.