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首页> 外文期刊>Placenta >Effects of sFlt-1 and alpha 2-macroglobulin on vascular endothelial growth factor-induced endothelin-1 upregulation in human microvascular endothelial cells.
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Effects of sFlt-1 and alpha 2-macroglobulin on vascular endothelial growth factor-induced endothelin-1 upregulation in human microvascular endothelial cells.

机译:sFlt-1和α2-巨球蛋白对人微血管内皮细胞中血管内皮生长因子诱导的内皮素1上调的影响。

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摘要

sFLT-1 suppressed the VEGF-induced the ET-1 expression of HMEC-1. However, α2M did not show a significant effect on the ET-1 expression that was induced by VEGF. The results suggest that a certain proportion of the bound form α2M-VEGF have a biological action involved in the pathophysiology of preeclampsia.
机译:sFLT-1抑制VEGF诱导的HMEC-1的ET-1表达。但是,α2M对VEGF诱导的ET-1表达没有显着影响。结果表明,一定比例的结合形式α2M-VEGF具有先兆子痫的病理生理学作用的生物学作用。

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