In vitro inhibitory potential of Cynara scolymus, Silybum marianum, Taraxacum officinale, and Peumus boldus on key enzymes relevant to metabolic syndrome

摘要

Boldocynara (R), a proprietary dietary supplement product consisting of the plants Cynara scolymus, Silybum marianum, Taraxacum officinale, and Peumus boldus, used to promote functions of the liver and the gallbladder. It was the aim of the present study to look from a different perspective at the product by investigating the in vitro potential of Boldocynara (R) as a combination product and its individual extracts on key enzymes relevant to metabolic syndrome. Peumus boldus extract exhibited pronounced inhibitory activities on alpha-glucosidase (80% inhibition at 100 mu g/ml, IC50: 17.56 mu g/ml). Silybum marianum had moderate pancreatic lipase (PL) inhibitory activities (30% at 100 mu g/ml) whereas Cynara scolymus showed moderate ACE inhibitory activity (31% at 100 mu g/ml). The combination had moderate to weak effects on the tested enzymes. In conclusion, our results indicate some moderate potential of the dietary supplement Boldocynara (R) and its single ingredients for the prevention of metabolic disorders. (C) 2015 Elsevier GmbH. All rights reserved.