Epigallocatechin gallate, ellagic acid, and rosmarinic acid perturb dNTP pools and inhibit de novo DNA synthesis and proliferation of human HL-60 promyelocytic leukemia cells: Synergism with arabinofuranosylcytosine

Saiko Philipp; Steinmann Marie-Therese; Schuster Heike; Graser Geraldine; Bressler Sabine; Giessrigl Benedikt; Lackner Andreas; Grusch Michael; Krupitza Georg; Bago-Horvath Zsuzsanna; Jaeger Walter; Fritzer-Szekeres Monika; Szekeres Thomas

首页> 外文期刊>Phytomedicine : >Epigallocatechin gallate, ellagic acid, and rosmarinic acid perturb dNTP pools and inhibit de novo DNA synthesis and proliferation of human HL-60 promyelocytic leukemia cells: Synergism with arabinofuranosylcytosine

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Epigallocatechin gallate, ellagic acid, and rosmarinic acid perturb dNTP pools and inhibit de novo DNA synthesis and proliferation of human HL-60 promyelocytic leukemia cells: Synergism with arabinofuranosylcytosine

机译：表没食子儿茶素没食子酸酯，鞣花酸和迷迭香酸扰动dNTP库并抑制人HL-60早幼粒细胞白血病细胞的从头DNA合成和增殖：与阿拉伯呋喃呋喃糖胞嘧啶的协同作用

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Epigallocatechin gallate (EGCG), ellagic acid (EA) and rosmarinic acid (RA) are natural polyphenols exerting; cancer chemopreventive effects. Ribonucleotide reductase (RR; EC 1.17.4.1) converts ribonucleoside diphosphates into deoxyribonucleoside diphosphates being essential for DNA replication, which is why the enzyme is considered an excellent target for anticancer therapy.

机译：表没食子儿茶素没食子酸酯（EGCG），鞣花酸（EA）和迷迭香酸（RA）是天然的多酚。癌症的化学预防作用。核糖核苷酸还原酶（RR; EC 1.17.4.1）可将核糖核苷二磷酸转化为脱氧核糖核苷二磷酸，这对DNA复制至关重要，因此，该酶被认为是抗癌治疗的理想靶标。

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《Phytomedicine :》 |2015年第1期|共10页
作者
Saiko Philipp; Steinmann Marie-Therese; Schuster Heike; Graser Geraldine; Bressler Sabine; Giessrigl Benedikt; Lackner Andreas; Grusch Michael; Krupitza Georg; Bago-Horvath Zsuzsanna; Jaeger Walter; Fritzer-Szekeres Monika; Szekeres Thomas;
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正文语种 eng
中图分类植物学;
关键词
Epigallocatechin gallate; Ellagic acid; Rosmarinic acid; Ribonucleotide reductase; Arabinofuranosylcytosine; HL-60 cells;

机译：表没食子儿茶素没食子酸酯;鞣花酸;迷迭香酸;核糖核苷酸还原酶;阿拉伯呋喃糖胞嘧啶;HL-60细胞;

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1. Epigallocatechin gallate, ellagic acid, and rosmarinic acid perturb dNTP pools and inhibit de novo DNA synthesis and proliferation of human HL-60 promyelocytic leukemia cells: Synergism with arabinofuranosylcytosine [J] . Saiko Philipp, Steinmann Marie-Therese, Schuster Heike, Phytomedicine : . 2015,第1期

机译：表没食子儿茶素没食子酸酯，鞣花酸和迷迭香酸扰动dNTP库并抑制人HL-60早幼粒细胞白血病细胞的从头DNA合成和增殖：与阿拉伯呋喃呋喃糖胞嘧啶的协同作用
2. N-hydroxy-N'-(3,4,5-trimethoxyphenyl)-3,4,5-trimethoxy-benzamidine, a novel resveratrol analog, inhibits ribonucleotide reductase in HL-60 human promyelocytic leukemia cells: Synergistic antitumor activity with arabinofuranosylcytosine [J] . Philipp Saiko, Maria Ozsvar-Kozma, Astrid Bernhaus, International journal of oncology . 2007,第5期

机译：N-羟基-N'-（（3,4,5-三甲氧基苯基）-3,4,5-三甲氧基-苯甲m
3. Fatty acids, inhibitors for the DNA binding of c-Myc|[sol]|Max dimer, suppress proliferation and induce apoptosis of differentiated HL-60 human leukemia cell [J] . K C Jung, C H Park, Y H Hwang, Leukemia . 2006,第1期

机译：脂肪酸，c-Myc | [sol] | Max二聚体的DNA结合抑制剂，抑制分化的HL-60人白血病细胞增殖并诱导其凋亡
4. Alternol Inhibits Proliferation and Induces Apoptosis in Human Leukemia HL-60 Cells [C] . Chen Ji, Li Defang, Zhang Bo, 5th International Conference on Bioinformatics and Biomedical Engineering . 2011

机译：交替烷抑制人白血病HL-60细胞的增殖并诱导其凋亡。
5. Effects of n-3 and n-6 polyunsaturated fatty acids on human promyelocytic HL-60 cells. [D] . Gillis, Robert Clements. 2003

机译：n-3和n-6多不饱和脂肪酸对人早幼粒细胞HL-60细胞的影响。
6. 4-(NN-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1 but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal [O] . James Russo, Annette Barnes, Katie Berger, 2002

机译：4-（NN-二丙基氨基）苯甲醛抑制ALDH1A1将全反式视网膜氧化为全反式维甲酸但不抑制暴露于全反式视网膜的HL-60早幼粒细胞白血病细胞的分化
7. A novel N-hydroxy-N′-aminoguanidine derivative inhibits ribonucleotide reductase activity: Effects in human HL-60 promyelocytic leukemia cells and synergism with arabinofuranosylcytosine (Ara-C) [O] . Philipp Saiko, Geraldine Graser, Benedikt Giessrigl, 2011

机译：一种新的N-羟基-N'-氨基胍衍生物抑制核糖核苷酸还原酶活性：人HL-60幼高细胞白血病细胞的影响和阿拉伯呋喃糖苷（ARA-C）的协同作用
8. Regulated expression of the MRP8 and MRP14 genes in human promyelocytic leukemic HL-60 cell treated with the differentiation-inducing agents mycophenolic acid and 1(alpha),25-dihydroxyvitamin D(sub 3) [R] . Warner-Bartnicki, A. L., Murao, S., Collart, F. R., 1992

机译：用分化诱导剂霉酚酸和1α，25-二羟基维生素D（sub 3）处理的人早幼粒细胞白血病HL-60细胞中mRp8和mRp14基因的调节表达

Epigallocatechin gallate, ellagic acid, and rosmarinic acid perturb dNTP pools and inhibit de novo DNA synthesis and proliferation of human HL-60 promyelocytic leukemia cells: Synergism with arabinofuranosylcytosine

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