RBE of α particles and postradiation recovery in a temperature conditional mutant of diploid yeast for various criteria of cell death

摘要

The influence of linear energy transfer (LET) on relative biological effectiveness (RBE) and the liquid-holding recovery (LHR) ability was studied for a temperature conditional mutant of diploid yeast. Both the RBE and the rate of LHR were much lower for reproductive killing at 36°C and cell killing without division at both 23 and 36°C. However, the probability of recovery was independent of the culture temperature being identical for both low-and high-LET radiations. It was concluded that the LHR process itself is not damaged after densely ionizing radiation, while the enhanced RBE value and the reduced rate and volume of recovery after high-LET radiation may be entirely caused by the increased yield of the irreversible radiation damages.