Functional genomics towards personalized healthcare. Proceedings of the 4th Biologie Perspective Santorini Conference. 2008. Santorini, Greece.

摘要

A goal of pharmacogenomics is to guide drug development and selection in order to optimize therapeutic benefits and minimize the potential risk of toxicity. Genetic-based differences in drug metabolism have been recognized for 50 years, but these are better understood since two accidents occured 30 years ago with anti-anginal drug perhexiline and the antidiabetic phenylbiguanide. Accordingly, there is a growing need for ways to better identify individuals who have the highest probability of benefiting from pharmacological interventions, and those who have the lowest risk of developing side effects when exposed to drugs.