ABCC10 rs2125739 polymorphism and nevirapine-induced hepatotoxicity: Lack of association in a population from Mozambique

摘要

Recently, in their paper 'Association of ABCC10 polymorphisms with nevirapine (NVP) plasma concentrations in the German Competence Network for HIV/AIDS', Liptrott et al. [ 1 ], described an exonic single-nucleotide polymorphism (SNP) (rs2125739) as significantly associated with the NVP plasma concentration (P = 0.02) in Whites: the variant allele was significantly more frequent in those with lower NVP plasma concentrations. Moreover, they observed a prevalence of the same allele also in Blacks with a lower NVP plasma concentration even though the difference did not reach statistical significance.