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Centenary of Karl Jaspers’s general psychopathology: implications for molecular psychiatry

机译:卡尔·贾斯珀斯百年精神病理学百年纪念:对分子精神病学的启示

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Modern molecular psychiatry benefits immensely from the scientific and technological advances of general neuroscience (including genetics, epigenetics, and proteomics). This “progress” of molecular psychiatry, however, will be to a degree “unbalanced” and “epiphytic” should the development of the corresponding theoretical frameworks and conceptualization tools that allow contextualization of the individual neuroscientific findings within the specific perspective of mental health care issues be neglected. The General Psychopathology , published by Karl Jaspers in 1913, is considered a groundbreaking work in psychiatric literature, having established psychopathology as a space of critical methodological self-reflection, and delineating a scientific methodology specific to psychiatry. With the advance of neurobiology and molecular neuroscience and its adoption in psychiatric research, however, a growing alienation between current research-oriented neuropsychiatry and the classical psychopathological literature is evident. Further, consensus-based international classification criteria, although useful for providing an internationally accepted system of reliable psychiatric diagnostic categories, further contribute to a neglect of genuinely autonomous thought on psychopathology. Nevertheless, many of the unsolved theoretical problems of psychiatry, including those in the areas of nosology, anthropology, ethics, epistemology and methodology, might be fruitfully addressed by a re-examination of classic texts, such as Jaspers’s General Psychopathology , and their further development and adaptation for 21st century psychiatry.
机译:现代分子精神病学极大地受益于普通神经科学(包括遗传学,表观遗传学和蛋白质组学)的科学和技术进步。但是,如果相应的理论框架和概念化工具能够在精神卫生保健问题的特定视角内对各个神经科学发现进行背景研究,则分子精神病学的这种“进展”将在一定程度上“不平衡”和“附生”。被忽视。由卡尔·贾斯珀斯(Karl Jaspers)于1913年出版的《普通精神病理学》被认为是精神病学文学中的开创性著作,它确立了精神病理学作为批判性方法学自我反思的空间,并描绘了一种专门针对精神病学的科学方法论。然而,随着神经生物学和分子神经科学的发展以及其在精神病学研究中的采用,显而易见的是,当前以研究为导向的神经精神病学与经典的精神病理学文献之间的疏远。此外,基于共识的国际分类标准尽管可用于提供国际公认的可靠的精神病学诊断类别系统,但进一步有助于忽略对精神病理学的真正自主思想。然而,许多尚未解决的精神病学理论问题,包括在语言学,人类学,伦理学,认识论和方法论领域的问题,可以通过重新研究经典文本(例如贾斯珀斯的《一般精神病理学》)及其进一步发展而得到有效解决。和适应21世纪的精神病学。

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