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Osteoprotegerin polymorphisms are associated with alcohol-induced osteonecrosis of femoral head in Chinese Han population from Henan province

机译:骨保护素多态性与酒精引起的河南省汉族人群股骨头坏死有关

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Alcohol-induced osteonecrosis of femoral head (ONFH) is one of the most important pathogenesis of nontraumatic ONFH. However, its pathogenesis mechanism is still unknown. Osteoprotegerin (OPG) has been implicated in multiple functions including blocking osteoclast maturation, controlling vascular calcifications, promoting tumour growth and metastasis. This study is focussed on OPG gene polymorphisms associated with alcohol-induced ONFH. A total of 509 participants (209 patients and 300 normal individuals) were recruited, and we selected 13 single-nucleotide polymorphisms (SNPs) to evaluatethe association between genetic susceptibility variants and alcohol-induced ONFH by using the ???2 test and genetic model analysis. Overall, OPG SNPs (rs1485286, rs1032128 and rs11573828) were confirmed the strongest increasing risks on alcohol-induced osteoporosis of femoral head in recessive model (rs1485286: OR, 1.71; 95% CI, 1.07a€“2.73; P = 0.025 for T/T); (rs1032128: OR, 1.73; 95% CI, 1.08a€“2.77; P = 0.022 for G/G); (rs11573828: OR, 3.89; 95% CI, 1.02a€“14.85; P = 0.033 for T/T). SNP rs11573856 was considered as a protective effect to the occurrence of alcohol-induced ONFH, while adjusted for age and gender in dominant and log-additive models (rs11573856: adjusted OR, 0.60; 95% CI, 0.37a€“0.96; P = 0.033 for G/Aa€“A/A); (rs11573856: adjusted OR, 0.63; 95% CI, 0.41a€“0.96; P = 0.042). We conclude that OPG gene polymorphisms were associated with the occurrence of alcohol-induced ONFH.
机译:酒精引起的股骨头坏死(ONFH)是非创伤性ONFH最重要的发病机制之一。但是,其发病机理仍是未知的。骨保护素(OPG)涉及多种功能,包括阻断破骨细胞成熟,控制血管钙化,促进肿瘤生长和转移。这项研究的重点是与酒精诱导的ONFH相关的OPG基因多态性。总共招募了509名参与者(209名患者和300名正常个体),我们选择了13个单核苷酸多态性(SNP),以利用??? 2检验和遗传模型评估遗传易感性变异与酒精诱导的ONFH之间的关联。分析。总体而言,在隐性模型中,OPG SNP(rs1485286,rs1032128和rs11573828)被证实在酒精引起的股骨头骨质疏松症中增加的风险最大(rs1485286:OR,1.71; 95%CI,1.07a?2.73; T = 0.025) / T); (rs1032128:OR,1.73; 95%CI,1.08a?2.77;对于G / G,P = 0.022); (rs11573828:OR为3.89; 95%CI为1.02a-14.85; T / T为P = 0.033)。 SNP rs11573856被认为对酒精诱导的ONFH的发生具有保护作用,而在显性和对数加性模型中对年龄和性别进行了调整(rs11573856:调整后的OR,0.60; 95%CI,0.37a“ 0.96; P = G / Aa:“ A / A”为0.033; (rs11573856:调整后的OR为0.63; 95%CI为0.41a?0.96; P = 0.042)。我们得出结论,OPG基因多态性与酒精诱导的ONFH的发生有关。

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