Determination of Prothrombin Time, Activated Partial Thromboplastin Time and D-Dimer Levels among Malaria Infected Patients in Sinnar State, Sudan

摘要

Malaria is one of the major causes of disease for people living in tropical and subtropical areas. Blood coagulation activation is frequently found in patients with malaria. The aim of the current study is to assess prothrombin time, activated partial thromboplastin time and D-dimer in patient suffering from malaria. This study includes 50 patients who have malaria parasite and 50 persons as control. Sandwich chemiluminescence immunoassay uses ABEI to label an anti-D-dimer monoclonal antibody and uses another D-dimer monoclonal antibody to coat magnetic microbeads. Prothrombin Time (PT) and Partial Thromboplastin Time (PTT) were measured for all case and control and SPSS software was used to evaluate the correlation. Results of D-dimer in all patient in mean were 1.92 ± 1.09 ng/ml; the D-dimer level was significantly higher among patients (p value = 0.00) compared to control (0.41 ± 0.10 ng/ml). PT in patient in mean was 16.34 ± 2.67 seconds and the mean of PT result in control was 14.29 ± 0.92 seconds; the mean of INR results in patients was 1.22 and the mean of INR results in control was 1.19. The results of PTT in patients in mean were (30.40 ± 4.73 second) and the mean of PTT results in control were (27.82 ± 1.49 seconds). Also, our result shows no statistically significant in PT, APTT and D-dimer between male and female. In conclusion, our study revealed higher D-dimer levels, PT and APTT among patient with Malaria, while the gender showed no effect on the level of D-dimer levels, PT and APTT.