首页> 外文期刊>African Journal of Microbiology Research >Prevalence of IgG and IgM antibodies to Chikungunya virus among outpatients with febrile illness attending University of Maiduguri Teaching Hospital, Maiduguri, Borno State, Nigeria
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Prevalence of IgG and IgM antibodies to Chikungunya virus among outpatients with febrile illness attending University of Maiduguri Teaching Hospital, Maiduguri, Borno State, Nigeria

机译:在尼日利亚博尔诺州迈杜古里大学迈杜古里大学教学医院就诊的发热患者中,针对基孔肯雅病毒的IgG和IgM抗体的患病率

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In Nigeria, there is paucity of information on the epidemiology of infections due to Chikungunya virus (CHIKV) especially among patients with febrile illness. Cases of febrile illness are usually associated with malaria and typhoid fever without considering the possibility of viral aetiology. This study was designed to determine the prevalence and identify other epidemiological parameters of CHIKV infections among outpatients with febrile illness attending University of Maiduguri Teaching Hospital, Nigeria. Sera from 370 patients were tested for presence of CHIKV immunoglobin (Ig) IgM and IgG antibodies using the enzyme-linked immunosorbent assay (ELISA). Of the 370 sera tested, 39 (10.5%) were positive for presence of CHIKV antibodies. A total of 24 (6.5%) tested positive for CHIKV IgM only, while none (0.0%) was positive for the presence of CHIKV IgG only. Fifteen (4.1%) of the serum samples simultaneously reacted to both IgG and IgM antibodies. A significant difference (p<0.0001) was observed in the distribution of CHIKV antibodies in relation to gender. The males had prevalence of 8.5% IgM antibodies as against 4.6% in females, 4.6% of females were positive for both CHIKV IgG and IgM antibodies, compared to 3.4% in males. The age group ≤60 years and the undisclosed age group were positive for the presence of CHIKV IgG and/or IgM antibodies. No significant difference was observed in the seasonal prevalence of CHIKV antibodies among the study subjects. Analysis of the prevalence of CHIKV antibodies in relation to clinical presentation in the patients revealed that headache and fever were the most frequently encountered ailments.
机译:在尼日利亚,关于基孔肯雅病毒(CHIKV)引起的感染的流行病学信息很少,尤其是在高热病患者中。高热病病例通常与疟疾和伤寒有关,而没有考虑病毒病因的可能性。本研究旨在确定在尼日利亚梅杜古里大学教学医院就诊的高热病门诊患者中CHIKV感染的患病率并确定其他流行病学参数。使用酶联免疫吸附测定(ELISA)检测了370位患者的血清中是否存在CHIKV免疫球蛋白(Ig)IgM和IgG抗体。在测试的370个血清中,有39个(10.5%)的CHIKV抗体阳性。总共24(6.5%)只对CHIKV IgM呈阳性,而没有(0.0%)仅对CHIKV IgG呈阳性。十五(4.1%)血清样品同时与IgG和IgM抗体反应。观察到CHIKV抗体在性别分布上的显着差异(p <0.0001)。男性的IgM抗体患病率为8.5%,女性为4.6%,CHIKV IgG和IgM抗体阳性的女性为4.6%,男性为3.4%。 ≤60岁的年龄组和未公开年龄组的CHIKV IgG和/或IgM抗体阳性。在研究对象之间,CHIKV抗体的季节性患病率未观察到显着差异。对患者中CHIKV抗体与临床表现的相关性进行分析后发现,头痛和发烧是最常见的疾病。

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