A Review on Analytical Methods for the Determination of Palonosetron in Pharmaceutical Formulation

摘要

Palonosetron is a second-generation 5-HT3 receptor antagonist with an extended half-life of approximately 40 hours and high binding affinity for the 5-HT3 receptor that is markedly different from other 5-HT3 receptor antagonists. Phase III trials demonstrate that a single dose of palonosetron compared with traditional 5-HT3 receptor antagonists is more effective in preventing chemotherapy-induced nausea and vomiting during the first 24 hours following chemotherapy, and also exhibits prolonged efficacy to provide significantly better protection from nausea and vomiting in the delayed and overall phases. This review article accentuates various analytical methods viz. HPLC, HPTLC, spectrophotometric, electrochemical, capillary electrophoresis and LC– MS for the estimation of palonosetron in pharmaceutical formulations and in biological matrices.